منابع مشابه
Silent Synapses Speak Up
*Department of Psychiatry The existence of silent or ineffective synapses in the †Department of Cellular and Molecular spinal cordwas proposed over 20 years ago (Wall, 1977), Pharmacology based on experimentally induced rapid changes in the Department of Physiology ability of afferents to evoke single unit activity. However, University of California a limitation of this approach was that it was...
متن کاملSilent clusters – speak up!
Microorganisms have provided mankind with a multitude of useful compounds ranging from industrial enzymes to anti-cancer compounds and antibiotics. With the aging population, our need for treatment principles against cancer, Alzheimer's disease and metabolic disorders is increasing. Also, the occurrence and spread of antibiotic resistance in pathogenic microorganisms has become one of our main ...
متن کاملSilent pericentromeric repeats speak out.
Pericentromeres are essential structural components of the chromosome that function to ensure proper sister chromatid segregation during cell division. These chromosomal domains are composed of major satellite DNA repeats whose constitutively heterochromatic structure facilitates kinetochore formation (1). Characteristically demarcated by the silencing histone mark trimethyl-histone-3lysine-9, ...
متن کاملPresynaptically Silent Synapses Studied with Light Microscopy
Synaptic plasticity likely underlies the nervous system's ability to learn and remember and may also represent an adaptability that prevents otherwise damaging insults from becoming neurotoxic. We have been studying a form of presynaptic plasticity that is interesting in part because it is expressed as a digital switching on and off of a presynaptic terminal s ability to release vesicles contai...
متن کاملIn Vivo Cocaine Experience Generates Silent Synapses
Studies over the past decade have enunciated silent synapses as prominent cellular substrates for synaptic plasticity in the developing brain. However, little is known about whether silent synapses can be generated postdevelopmentally. Here, we demonstrate that highly salient in vivo experience, such as exposure to cocaine, generates silent synapses in the nucleus accumbens (NAc) shell, a key b...
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ژورنال
عنوان ژورنال: Neuron
سال: 1997
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(00)80362-1